parabolan cycle

PHARMACOLOGICAL PROPERTIES Pharmacodynamics Both active substance included in the preparation parabolan cycle, estriol and lactobacilli Parabolan cycle , are involved in the physiological mechanism of maintaining normal biotsinoza vagina. Parabolan cycle – one of the dominant vaginal microorganisms healthy woman having antagonistic activity against pathogenic and conditionally pathogenic microorganisms . estriol – estrogen is a short-acting, has a protective effect on trophic vaginal epithelium and has no systemic effects on a woman’s body. Proliferating mature vaginal epithelium glycogen accumulates in itself necessary for the operation of lactobacilli, which, in turn, produce lactic acid, keeping the acidic environment of the vagina (pH 3.8-4.5), which creates unfavorable conditions for the development and colonization of pathogenic microorganisms. Furthermore lactic acid, Parabolan cycleproduce hydrogen peroxide and bacteriocins, and inhibits the development of pathogenic and conditionally pathogenic microorganisms. Changing the vaginal physiological flora is due to various factors, local or systemic use of antimicrobials, including due to vaginal infections, systemic diseases, poor hygiene. In these cases, the number of lactobacilli can be significantly reduced. Vaginal application parabolan cycle improves the condition of the vaginal epithelium and restores its normal flora. Lactose, which is contained in a vaginal tablets as a filler, can also be fermented by lactobacilli to lactic acid. The vaginal epithelium is thinner and can be damaged and hormonal disturbances, and therefore parabolan cycle can be used in postmenopausal women, weakening its local symptoms (pruritus, burning, vaginal dryness, pain during intercourse), promoting the normalization of the epithelium of the vagina and urethra, reducing the incidence of degenerative inflammatory conditions. in vitro demonstrated that Parabolan cycle for several hours leads to the desired pH reduction and estriol, treatment duration with 6-12 days proliferative provides trophic effect on the vaginal epithelium.

Pharmacokinetics
With the introduction of the drug into the vagina, lyophilized bacteria are released and estriol.
The absorption of estriol from parabolan cycle studied in postmenopausal women. After repeated use of the drug concentration in plasma corresponds to the concentration of endogenous unbound estriol. After the 12th day of application of vaginal tablets during treatment parabolan cycle (1 per day), the maximum concentration of unbound estriol plasma does not differ from the original, indicating a lack of systemic absorption.
The product has no effect on the concentration of estrone and estradiol in plasma blood as estriol is the final product of their metabolism.

Indications

  • Recovery flora Parabolan cycle after local and / or systemic antibiotic treatment or other chemotherapeutic agents
  • Estrogenzavisimye atrophic vaginitis in postmenopausal women, including in conjunction with hormone replacement therapy (HRT)
  • Bacterial vaginosis

Contraindications

  • Hypersensitivity to the drug or its components;
  • Malignant neoplasms of estrogen-dependent, including breast, uterus and vagina (diagnosed with a history, and is suspected to them);
  • Endometriosis (suspected or diagnosed);
  • Vaginal bleeding of unknown etiology;
  • Application of the girls before sexual debut;
  • Untreated endometrial hyperplasia.

Pregnancy and lactation
Application in I trimester of pregnancy is not desirable. Perhaps the use of the drug parabolan cycle in II-III trimesters of pregnancy and lactation. Adverse effect of lactobacilli and estriol on pregnancy and the fetus / newborn were found. However, long-term clinical studies on the effects of estriol on the fetus have not been conducted.

Dosing and dose
vaginal tablets should be inserted deep into the vagina at night before bedtime, better lying on his back slightly bent knees. To restore the flora of Parabolan cycle after topical and / or systemic treatment with antibiotics or other chemotherapeutic agents, as well as in the treatment of bacterial vaginosis : 1-2 vaginal tablets daily for 6-12 days. in the treatment of estrogen-dependent atrophic vaginitis in postmenopausal women : 1 vaginal tablet daily for 6-12 days, followed by a maintenance dose of 1 vaginal tablet 1-2 times a week .

Side effect
Probably burning sensation (heat) into the vagina rarely redness and itching of the vulva and vagina.

Overdose
An overdose of the drug was observed. The interaction with other drugs Parabolan cycle susceptible to numerous antibacterial drugs (local or systemic application). Concomitant treatment with these agents may reduce the effectiveness of parabolan cycle.

Cautions
parabolan cycle contains components that can not be dissolved completely, the remains of the vaginal tablets can sometimes be found on the underwear. The effectiveness of the drug is not affected.
In rare cases, if vaginal dryness, vaginal tablets can not dissolve. To prevent such cases, prior to introducing the tablet may be a small amount of conventional hydrated water – this will contribute to its more rapid dissolution. Patients were encouraged to use liners.

Effects on ability to drive and use other mechanisms
parabolan cycle does not affect the ability to drive and use machines.

Form release
Tablets vaginal. On 6 tablets in blisters of aluminum foil and PVC film.
1 or 2 contour cell packages with instruction on the medical application are placed in a pile of cardboard.

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