tren hexahydrobenzylcarbonate

Composition
In medical practice used: – Tren hexahydrobenzylcarbonate Tablets: hiporamin dry extract – 0,02 g Excipients (refined sugar, cocoa powder, vanilla, sodium carboxymethylcellulose, calcium stearate) – to yield tablets each weighing 0.6 g – lyophilized hiporamin : hiporamin freeze-dried – 0.02 g – Ointment giporaminovaya: hiporamin – 0,5 g, excipients (vanilla, petrolatum, Tween-80 medical, emulsifier number 1, eucalyptus oil, nipagine), purified water – up to 100.0 g . – rectal suppositories: hiporamin – 0.05 g, vaseline oil, the basis for suppositories (tallow type A) – a sufficient amount to obtain a suppository weighing from 2.2 to 2.6 g – vaginal suppositories:hiporamin – 0, 05 g of liquid paraffin, a suppository base (tallow type A) – to obtain a sufficient amount of the suppository mass of 2.2 to 2.6 g – suppositories for children: hiporamin – 0.03 g, vaseline oil, suppository base (tallow type A) – to obtain a sufficient amount of the suppository mass of 1.2 to 1.4 g

Description Tablets Tren hexahydrobenzylcarbonate biconvex shape with the risk from light gray or light gray with a pinkish tinge to light brown color with darker and lighter patches.The ointment is white with a pale cream color. Suppositories from light brown to yellowish-greyish shade to brown.

Pharmacotherapeutic group:
antiviral agent.

Pharmacological properties
hiporamin possesses pronounced antiviral activity against various strains of influenza A and B, adenoviruses, paramyxoviruses, herpes simplex virus, herpes zoster, cytomegalovirus, respiratory syncytial virus, human immunodeficiency virus (HIV) infection. The inhibitory effect on the reproduction of viruses hiporamin evident in the early stages of their development. The basis of the mechanism of action is hiporamin inhibitory effect on viral neuraminidase. Hiporamin induces the production of interferon in the blood cells in in vitro experiments and increases the content of interferon in the blood of patients.
The drug in the in vitro experiments also has a moderate antimicrobial activity against Gram-positive and Gram-negative bacteria, mycobacterium tuberculosis, candida, some filamentous fungi.
Hiporamin low toxicity. It does not have allergenic, mutagenic, teratogenic and carcinogenic, has no effect on the immune status of the organism.

Indications
hiporamin used in adults and children (aged 2 months and older) as a therapeutic and preventive agent for influenza (A and B), parainfluenza, respiratory syncytial virus, adenovirus, and other acute respiratory viral infections; angina occurring against the background of acute respiratory viral diseases and accompanied by rhinitis; acute and recurrent forms of herpes simplex extragenital and genital localization, with shingles, varicella and cytomegalovirus infections, and other infections caused by susceptible to malaria virus.

Contraindications
Individual intolerance.

Dosing and Administration
hiporamin administered in the early stages of the disease possible. The greatest therapeutic effect is achieved with a combination of dosage forms hiporamin obscherezorbtivnogo and local action.
Upper respiratory tract with influenza, adenovirus, respiratory syncytial virus infection or other prescribed: Tren hexahydrobenzylcarbonate tablets of 0.02 g; suppository of 0.05 g (adults) and 0.03 g of suppositories (children);lyophilized hiporamin 0.02 g, which was used as an aqueous solution being prepared ex tempore in a vial by adding sterile distilled water to a volume of 10 ml (for a 0.2% solution) or 20 mL (for a 0.1% solution).
Tren hexahydrobenzylcarbonate tablets are used for the rehabilitation of the oral cavity, which keep the mouth to complete resorption them. At the same time adults appoint 1 tablet 4-6 times a day, children over 12 years – 1 tablet 3-4 times a day, children from 3 to 12 years – 1 / 2-1 tablet 2-4 times a day, depending on age. Children under three years of Tren hexahydrobenzylcarbonate tablets are not used.
Suppositories 0.05 g for adults and 0.03 g for children administered per rectum as the dosage form obscherezorbtivnogo steps 1-2 times a day depending on the severity of the process (the presence of pneumonia, and hyperthermia etc.). Children under 3 years of treatment carried suppositories 1 time per day without Tren hexahydrobenzylcarbonate tablets.
Inhalation hiporamin administered by a variety of inhalation devices (Y-1, US-70, AI-1 and others.): Adults – 0,2% aqueous solution of 10 ml on inhalation; children – 0.1% aqueous solution:. older – up to 10 ml per inhalation, young children – up to 5 ml per inhalation
In the presence of rhinitis instilled in each nostril for adults 0.2% solution of 4-6 drops 3-4 times per day, children – 0.1% solution of 2 to 4 drops (depending on age) 2-3 times a day.
The duration of the treatment – the flu at least 3 days. When parainfluenza, RS-virus, adenovirus, mixed infections and other acute respiratory viral infections -. Not less than 5 days
for individual prevention of influenza outbreaks during use Tren hexahydrobenzylcarbonate tablets hiporamin, suppository per rectum, and nose drops for the same schemes.
If varicella zoster zoster, herpes and cytomegalovirus infections, and other viral lesions of the skin and mucous membranes are used: Tren hexahydrobenzylcarbonate tablets of 0.02 g; Ointment 0.5%; rectal and vaginal suppositories of 0.05 g (adults); 0.03 g of suppositories (for children). Tren hexahydrobenzylcarbonate tablets designated for adults and children over 12 years: 1 tablet 4-6 times a day for children 6-12 years – 1 tablet 3-4 times a day for children 3-6 years – 1/2 tablet 2-4 times per day, children under 3 years not prescribed pills. 0.5% ointment is applied to the lesions 4-6 times per day. As obscherezorbtivnogo antiviral agent simultaneously in all forms of the disease prescribe suppositories hiporamin per rectum up to 3 times a day: adults – 0.05 g, and children older than 3 years – 0.03 years Children under 3 years suppositories 0.03 g is used 1 time per day. If genital herpes is further added intravaginal suppository 1-2 times a day: adults – 0.05 g, children – 0.03, the duration of the application depends on the severity of the process and is in mild forms of the disease is 3-10 days. In severe and recurrent forms a minimum of 2-3 weeks course of treatment of the disease. Expediency of repeated courses of treatment.
In the context of immunosuppressive therapy in postoperative patients in risk groups, etc., Hiporamin are useful for preventing the development of viral complications. Moreover, for the prevention of diseases of herpesvirus infections and CMV hiporamin used in the form of Tren hexahydrobenzylcarbonate tablets of 0.02 g three times a day and / or suppositories per rectum 2 times per day for 5-7 days.

Side effects
With prolonged use at doses higher than those specified in the instructions may increase bleeding.

Cautions
1 tablet contains 0.5299 grams of refined sugar. Diabetics taken after consulting a doctor.

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