What is tren is a blocker of histamine, and moderate blocks serotonin , thereby weakening the effect of mediators of allergy histamine and serotonin. Histamine causes the clinical manifestations of allergic inflammation: swelling (increased capillary permeability), flushing of the skin (vasodilation), itching and pain. What is trena feature consists in the fact that it has protivogistaminnoe action not only blocking the H 1 receptors, but also reducing the content of histamine in tissues by accelerating its destruction diamine. In allergic diseases also increases the level of serotonin in the blood. Serotonin increases blood pressure, causes bronchospasm, increased capillary permeability, enhances the action of inflammatory mediators – histamine, bradykinin. prostaglandins. What is tren prevents or reduces spazmogennoe influence of histamine and serotonin in the smooth muscles of the bronchi, intestines, blood vessels; violation of capillary permeability and edema development. What is tren has a significant antipruritic and antiekssudativnoe do next Continue the gel character. Influences on the immunological reactivity of the organism, reducing the amount of antibody and rosette cells in the spleen, bone marrow, lymph nodes, and reduces the increased concentration of the immunoglobulin classes A and G. Slightly penetrates the blood-brain barrier than explains the absence of pronounced inhibitory effect on the central nervous system, but in some cases, the individual sensitivity observed light sedation. when receiving . quickly absorbed from the gastrointestinal tract. The maximum concentration of active compound in plasma is achieved in 1-2 hours. Predominantly accumulates in the lungs, the liver, the lowest concentration – in the brain. It is metabolized by oxidation to form a pharmacologically inactive metabolite. After receiving the single 50 mg dose half-life of the active substance from blood plasma is 12 hours, and after repeated doses of shorter half-life to 5.8 hours, ie the drug is not cumulated in the body. 50% of the dose excreted in the bile, more than 20% – with urine. About 30% of the dose are displayed unchanged, 40-50% in the form of metabolites.
Allergic rhinitis, conjunctivitis, hay fever, urticaria, angioedema, allergic pruritic dermatoses, including atopic dermatitis.
: Hypersensitivity to the active substance or excipients of the drug. Bronchial asthma. Pregnancy, lactation.
Simultaneous treatment with MAO inhibitors.
Precautions – for violations of renal function (treatment start with the lowest dose) and liver.
Dosing and Administration
Inside, after eating, squeezed water. Adults: 50-100 mg 2-3 times a day. Typically, the therapeutic effect occurs within 3 days after starting treatment. Duration of treatment is 5-15 days.
dry mouth, mild epigastric pain, dyspepsia, increased appetite.
Rarely – leukopenia, menstrual disorders, frequent urination, headache, somnolence.
Excitation, insomnia, which often occur at high doses.
Overdose Symptoms: dry mucous membranes, headache, vomiting, abdominal pain. Treatment: symptomatic therapy. The antidote is not known.
Interaction with other medicinal products.
What is tren does not enhance the inhibitory effect of hypnotic drugs and alcohol on the central nervous system, but in the period of treatment should refrain from drinking alcohol.
There are no clinical studies on the use of the drug for children and senile patients (after 70 years) age.
What is trena Tablets can be combined with topical therapy (ointment, compresses, eye drops, nasal drops).
In most cases, drowsiness decreases or disappears through 2- 5 days of starting treatment.
Effects on ability to drive vehicles: those whose work requires quick mental or physical reaction (transport drivers, and others.), in the period of treatment should refrain from driving motor vehicles and occupations potentially hazardous activities.
tablets of 50 mg. 10 tablets in blisters. 10, 20, 30, 40 or 50 tablets per plastic vials. Each vial or 1, 2, 3, 4 or 5, the contour of cellular packaging together with instructions for use are placed in a pile of cardboard.
2 years. Do not use after the expiration date.